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Additionally, individuals on long-term proton pump inhibitors (PPIs) or metformin therapy are at increased risk due to drug-related malabsorption
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In human-equivalent dosing calculations (using the FDA conversion factor of 0.162 for mouse-to-human translation), this translates to approximately 48 mg/kg for a 70 kg individual
A single 10 mg vial provides 24 days of material at these doses
Nature 458 , 11311135 (2009)
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