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2022;27:7728 Shibata Y, Chiba M

BMJ Open , 11 (2), e038933

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This triple-agonist approach creates metabolic effects that exceed what any single or dual-receptor compound achieves alone

Free Esa1/hMOF/GCN5 lacks HCT activity in vitro, but gains this activity upon forming complexes (e.g., the Esa1-Yng2-Epl1 complex or the Gcn5-Ada2-Ada3 complex) (Kollenstart et al