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Feedback inhibition of methylene-tetrahydrofolate reductase in rat liver by S-adenosylmethionine

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It is important to note that in BRCA1-deficient mammary cells, activation of NRF2 via small interfering RNA inhibition of KEAP1 rescued the survival defect linked with loss of BRCA1 and caused ROS levels restoration, indicating that this mechanism is important (237, 240)