In the SURPASS-1 trial, investigators reported an approximate 26% reduction in total fat mass compared with placebo
A practical way to read the two cadences together: the weekly 5-on/2-off rhythm is a fine-grained pause aimed at short-term receptor sensitivity, while the 812-on / 4-off macro-cycle is the coarse-grained pause aimed at the whole axis
This medication can be prescribed along with diet and exercise to help patients with a body mass index (BMI) of 30 or greater, or patients with a BMI of 27 or greater with at least one weight-related condition, such as type 2 diabetes or high blood pressure, to achieve weight loss
J Clin Invest 115 : 33933397 Cummings DE and Schwartz MW (2003) Genetics and pathophysiology of human obesity
For those taking concurrent diabetes medications, dose adjustments may be necessarythe Ozempic SmPC and BNF advise considering reduction of sulfonylurea or insulin doses when initiating GLP-1 receptor agonists to minimise hypoglycaemia risk
Stopping without medical advice Discontinuing abruptly may lead to weight regain and other issues