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The results were mixed both within and across studies, with no clear pattern emerging in any ROI examined by more than one study, except perhaps in the insula, where the majority of studies reported decreased activation to food-related cues after short- or long-term GLP-1 RA administration (see Figure 2 )
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Therefore, manipulation of the electrophysiological properties including the spontaneous firing activity of central neurons may play roles in the manifestation of some neurological disorders
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