Last reviewed: April 21, 2026 Updated with Phase 3 TRIUMPH-4 data Primary sources: NEJM, Eli Lilly, ClinicalTrials.gov Retatrutide is a triple agonist (GLP-1 + GIP + glucagon) currently in Phase 3 trials, showing stronger early weight loss data
Loss of pregnancy-associated plasma protein A extends lifespan in mice
Varying exercise routines prevents physiological adaptationthe body becomes efficient at repeated activities, so introducing new movements or intensities can enhance calorie burn
Acknowledgements This work was supported by the Natural Science Foundation of China (No
The gut microbiota and CVDs The human gut is colonized by approximately 100 trillion microorganismsincluding beneficial bacteria, neutral bacteria, and pathogenic bacteriawhich cooperate to maintain homeostasis of the gut microecology ( Bacteroidetes and Firmicutes account for approximately 90% of the total gut microbial abundance, followed by Proteobacteria (5-10%), Actinobacteria (3%), and Verrucomicrobia ( Intestinal dysbiosis refers to imbalance in the composition and abundance of gut microbiota and is associated with numerous diseases and phenotypes ( Supplementary Table 1 )
The nitric oxide hypothesis of migraine and other vascular headaches