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While all GLP-1 agonists share some common gastrointestinal effects, the triple agonism of retatrutide introduces glucagon receptor-mediated effects that the others do not produce

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Interestingly, an adjacent population of GABAergic neurons is activated by fasting but inhibited by the proopiomelanocortin (POMC) cleavage product alpha-melanocyte stimulating hormone (alpha-MSH), and their activation increases food intake [108]

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Lithium Lithium, particularly at low, non-psychiatric doses, represents another intriguing adjunct candidate

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