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3.3.4 Polyethylene glycol loxenatide The early GLP-1R agonist has many defects, such as multiple injections and a high incidence of adverse reactions in the digestive tract, which limits its clinical application

Beyond appetite suppression, Semaglutide also improves insulin secretion and reduces glucagon levels, helping to stabilize blood sugar and prevent insulin resistance

It suppresses IL-6, TNF-, and CRP while upregulating IL-10, thereby reducing myocardial inflammation (Yang et al., 2019

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The constant loading from daily activities makes complete rest nearly impossible