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Four of the six genes investigated by quantitative RT-PCR were significantly up-regulated by Exendin-4 pre-conditioning, including Lactate dehydrogenase A ( Ldha ), Aldolase A ( Aldoa ), Phosphofructokinase ( Pfkp ) and Glucose-6-phosphate isomerase ( Gpi ) (Fig

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It assists in the breakdown of glycogen to free up stored glucose for energy

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Alternatively, to extend the half-life of endogenous GLP-1, DPP-4 inhibitors are prescribed

EVs are novel and important carriers of signaling molecules in vivo , and a growing body of literature highlights the important role of EVs in the intercellular transmission of pathogenic protein aggregates, thus contributing to the understanding of the pathology and clinical progression of neurodegenerative diseases (68)