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In its mildest form, inflammation in the gut may induce only brief discomfort or food intolerance, whereas in the extreme, gut inflammation can manifest as Crohns disease or ulcerative colitis, with life threatening implications
Starting low and increasing slowly allows the body to adapt while minimizing reaction intensity
But, as always happens with big pharma blockbusters, the research community is busy exploring other possible applications for this class of compounds, with clinical trials underway or forming in cardiovascular disease, chronic kidney disease and obstructive sleep apnea
This approach helps to minimize side effects while maximizing the therapeutic benefits
and a brief handling reference