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The pathological features of PD, particularly iron accumulation, oxidative stress, and mitochondrial dysfunction, bear striking similarities to the hallmarks of ferroptosis
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Who Should Get Glutathione Shots
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and Steinhilber, D
Notably, targeting the structurally accessible P1P2 regions within pathogenic -syn oligomers and fibrils offers a promising therapeutic strategy for selectively inhibiting aggregation, thereby supporting the development of more effective disease-modifying treatments ( -syn filament architecture shared among PD, Parkinsons disease dementia (PDD), and dementia with Lewy bodies (DLB), which is distinct from the filament structures observed in multiple system atrophy (MSA) (Schweighauser et al., 2020)
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