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The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin

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Side effects that remain intolerable despite adaptation time may indicate the need for dose reduction

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These flavone compounds, including acacetin, baicalein, baicalin, chrysin, vitexin, scutellarein, kumatakenin, and apigenin-7-O-(6-p-coumaroyl)-glucoside, prevent and treat diseases by targeting multiple pathways to inhibit ferroptosis (ivanovi et al., 2024)