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Clinical Evidence: What the Data Shows Phase 3 Trial Results (Zepbound Studies) The REFRAME and related trials demonstrated: Weight Loss Average: 22.5% body weight reduction at 68 weeks Range: 18-28% depending on population Significantly exceeds tirzepatide (21% at comparable doses) Body Composition Preferential loss of visceral fat (the dangerous kind) Better preservation of lean muscle vs

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When to talk to your healthcare provider Contact your prescribing physician or healthcare provider if constipation persists despite fiber supplementation and complementary strategies for more than 3 weeks, if you experience severe abdominal pain, if you notice blood in your stool, if you develop symptoms of bowel obstruction (vomiting, inability to pass gas, severe abdominal distension), or if constipation is significantly impacting your quality of life or making you consider discontinuing your GLP-1 medication

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Drink immediately while warm, or pour into silicone molds and refrigerate for 23 hours to set into jiggly cubes