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Mitochondrion 50:113

Canapp SO Jr, Farese JP, Schultz GS, et al

160 Systemic administration of exenatide has been shown to suppresses conditioned place preference in cocaine-exposed mice

doi:10.1210/jc.2018-02241

Concerns Surrounding Compounded GLP-1s Mount As Shortages of Tirzepatide, Semaglutide End Luke Halpern, Associate Editor Key Takeaways Resolved shortages of tirzepatide and semaglutide have left compounded versions on the market, raising safety concerns due to lack of regulatory approval

The long half-life is driven by albumin binding (greater than 99% bound), reduced DPP-4 degradation due to the Aib8 substitution, and slowed renal clearance of the larger albumin-bound complex