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While pooled data from the SURPASS clinical trial programme indicate that tirzepatide does not increase the risk of major cardiovascular events [61], definitive conclusions regarding its cardiovascular profile should await the results of SURPASS-CVOT, with its completion anticipated in late 2024 [60]
For ashwagandha, insufficient safety data exist for lactationgenerally, it should be avoided
Blood 112(11):844, 2008
Medications are more likely to be covered for type 2 diabetes than for weight loss alone
In clinical studies, a combination containing piperine demonstrated its potential role in supporting the gut-hormone pathway that regulates appetite and glucose metabolism
This risk is one reason medical experts recommend delaying GLP-1 therapy until after weaning, when milk supply is no longer a concern
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