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aeruginosa strain lacking genes for glutathione ( gshA and gshB ) shows significantly higher susceptibility to carbenicillin, ciprofloxacin, and chloramphenicol

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However, during increased electron flux, superoxide production may reach a critical threshold, which may allow trafficking of superoxide anions through the mitochondrial transition pore into the cytosol, in which further damage and/or the activation of additional ROS sources may occur

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