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Studies measuring fibroblast proliferation markers show sustained upregulation for 4872 hours following a single AHK-Cu dose, which is why every-other-day or every-third-day protocols remain effective
moreover, it increases the expression of vascular endothelial growth factor, which is a potent angiogenic factor, whereas tumor necrosis factor-, interleukin-6, and nuclear factor kappa B expression are inhibited, which benefits the healing of diabetic wounds (Qiang et al., 2017
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