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And in 2021, the results from a series of five STEP trials (Semaglutide Treatment Effect in People with obesity) demonstrated marked weight loss even in individuals without type 2 diabetes (T2DM): Phase 3, for example, showed an average loss of about 15 percent over 68 weeks, more than double achieved by any prior obesity drug

These insights open new avenues for research into pathogenesis and the investigation of targeted approaches based on the modulation of proteasomal function

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3 Department of Surgery Innovation Center, Mayo Clinic, Rochester, MN, USA