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Cardiovascular Risk Reduction : For adults with type 2 diabetes and established heart and blood vessel disease, Semaglutide can significantly reduce the risk of major cardiovascular events like heart attack, stroke, or death

Sodhi A et al

Conversely, nicotine may exert paradoxical inhibitory effects by activating immune pathways and inducing apoptosis, such as through stimulation of immature dendritic cells via PI3K/Akt signaling and modulation of caspase-3 and Cyclin B1 expression through 7-nAChR signaling [36]

If you are losing 1-2 lbs/week at 4mg, the clinical benefit of escalating may not justify the additional $200-300/month

Supports cognitive function and neurological resilience

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