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High blood levels of homocysteine pose a risk for vascular and cognitive health

Moreover, several psychological factors significantly predict treatment dropout

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However, it has not been proven that ADU has clinical benefits in treating cognitive dysfunction in AD (64)

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For the identification of druggable targets, we considered three classes of enzymes: tier-1 targets, tier-2 targets, and other enzymes. Tier-1 targets correspond to enzymes whose knockout impedes viral replication while having a minimal impact on the simulated cellular viability