Long-term weight management after discontinuing tirzepatide requires acknowledging that obesity is a chronic, relapsing condition with biological underpinnings that persist after weight loss
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Clinicians should continue reporting safety concerns and monitoring patient outcomes carefully
The framework balances two equal goals: - Preventing organ dysfunction in those without complications by targeting fat mass accumulation - Reversing organ dysfunction in patients with complications such as type 2 diabetes, cardiovascular disease, MASLD, heart failure, or osteoarthritis This approach positions obesity treatment as disease modification, emphasizing protection of the heart, liver, pancreas, joints, and lungs beyond weight reduction alone EASO Framework: #EASO #Tirzepatide #Semaglutide #GLP1RAs #Getzpharma To view or add a comment, sign in Chronic kidney disease (CKD) is highly heterogeneous with different etiologies and mechanisms believed to underlie diabetic kidney disease (DKD), glomerulonephritis (GN), and hypertensive nephropathy (HTN)
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