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This novel dual-agonist approach surpassed the efficacy of monotherapy while maintaining a favorable costbenefit and safety profile [122]

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SUSTAIN-6, which showed cardiovascular safety for semaglutide, also had a flozin-like 26% reduction in CV death, heart attack, or stroke (Figure 7)

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Plasma was collected after centrifugation (3000 g , 10 min at 4 C) and stored at 80 C until assay

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