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While they did not investigate the directional sensitivity of the cerebral circulation in this study, their findings do support adaptation in the inherent directional sensitivity of the cerebral pressure-flow relationship

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Together, these medications provide robust HbA1c reduction with minimal hypoglycaemia risk, making them particularly valuable for patients requiring treatment intensification beyond metformin-based therapy

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Concurrent use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), or dopamine agonists/antagonists may produce unpredictable additive or counteractive effects