Residual AMPK activation from KLOW will interact with whatever the second intervention does, confounding attribution
The literature on NAC rescue for acetaminophen overdose makes it clear that early rescue is important[10, 55, 56]
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Suppression of SNAIL2, a zinc finger protein member of the SNAIL superfamily of epithelial-mesenchymal transition-inducing transcription factors (EMT-TFs) commonly overexpressed in pancreatic cancer patients, restored sensitivity of pancreatic cancer cell lines KLM1 and KMP5 to chemotherapy drug gemcitabine through an IGF binding protein 2 (IGFBP2)-dependent mechanism in vitro and in vivo (50)