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Neurogenic inflammation (inflammation that affects the peripheral nervous system, a network of nerves that runs throughout the head, neck, and body) and neuroinflammation (inflammation that affects the brain and spinal cord) are involved in migraines with and without auras and chronic migraines, according to a study published in the journal FASEB BioAdvances

Furthermore, MC1R's role may extend beyond pigmentation to include potential actions on anti-inflammatory signaling and the genomic stability of melanocytes, underlining the receptor's multifaceted potential in skin function and disease prevention

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