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A 2024 clinical trial published in JAMA Network Open divided weight-loss patients into three groups: exercise-only, GLP-1 medication-only, and GLP-1 medication combined with exercise

Semaglutide is a longacting glucagonlike peptide1 (GLP1) receptor agonist a synthetic analogue of the natural GLP1 hormone that binds to and activates the GLP1 receptor

Overuse does not necessarily improve outcomes and may increase the risk of irritation

Experts think cannabis might indirectly affect body weight by easing pain, stress, and insomnia, which can help some people move more and eat less

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