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A 2019 review in Aging Cell noted that metformin reduced circulating TNF-alpha by 17% and IL-6 by 24% in a pooled analysis of 664 patients with type 2 diabetes across four randomized controlled trials [9]

10.1038/s41416-021-01383-0 Summary Keywords oxidative stress, endogenous antioxidant, exogenous antioxidant, cancer prevention, Mendelian randomization study Citation Zhu J, Lian J, Wang X, Wang R, Pang X, Xu B, Wang X, Li C, Ji S and Lu H (2023) Role of endogenous and exogenous antioxidants in risk of six cancers: evidence from the Mendelian randomization study

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