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Furthermore, GLP-1 analogs may restore insulin secretion by activating the GLP-1 receptor (GLP-1R)-Gs signals because GLP-1 analogs overcome SSTR5-Gi signals in pancreatic -cells under the condition of suppressed insulin production and spare suppressed incretin secretion from intestinal L-cells 27

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2 Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116044, Peoples Republic of China

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