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A 2025 randomised crossover trial published in Nature Medicine (Pasqua et al.) tested weekly semaglutide alongside automated insulin delivery in adults with T1D
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When cells become insulin resistant, this suppression fails, and the liver churns out VLDL even when it shouldnt
Morbidity and mortality weekly report Surveillance summaries (Washington, DC : 2002)
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In Figure 1, tirzepatide was initiated at a dose of 2.5 mg once weekly (except placebo) and was increased by 2.5 mg every 4 weeks up to a maintenance dose of either 5 mg, 10 mg, or 15 mg
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