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100mcg = 0.02mL = 2 units 250mcg = 0.05mL = 5 units The second concentration requires smaller volumes but makes precise measurement more difficult

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A small randomized study (5) with N=60 patients where melatonin was orally administrated (3mg/day) from day 3-5 until hCG administration (oocyte collection) showed: a higher number of total oocytes (11.5 vs 6.9) higher number of mature oocyte (9% vs 4.4%) a higher rate of embryos transferred (69.3% vs 44.8%) These results were confirmed in another independent trial (6)

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