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doi:10.3389/fimmu.2018.02069 19
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Involvement of nuclear factor-kappa B (NF-B) in methotrexate-induced intestinal injury NF-kB is a key regulator of inflammation that is involved in the synthesis of inflammatory mediators and activation of pro-inflammatory cytokines (Liu et al
doi:10.4254/wjh.v6.i1.9
These processes collectively contribute to IR and, ultimately, T2DM [70]
Example Based on these entries in the ICD-10-CM Alphabetic Index there is a presumed link between diabetes and osteomyelitis unless stated otherwise, but a link between diabetes and cellulitis is not presumed and would require querying to link the two if a causal relationship is not documented by the physician
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