For weight management, semaglutide should be discontinued if pregnancy is recognized
Important safety considerations include a boxed warning for thyroid C-cell tumors, contraindication in patients with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2, and precautions regarding pregnancy (not recommended), reduced oral contraceptive effectiveness, and risks of pancreatitis, gallbladder disease, and acute kidney injury
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The gastric balloon could be an option for patients who are not good candidates for surgery or dont respond well to weight-loss drugs, Traverso says
Its primarily used for diabetes but has gained popularity for weight loss as well. Zepbound, which uses the same active ingredient as Mounjaro but is approved for weight loss, costs about $1,000 per fill without insurance. The cost of compounded semaglutide can vary based on the pharmacy and formulation
A double-blind, placebo-controlled study found that patients on memantine had a substantial response, suggesting that it could be a justified treatment for these disorders