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The concentration of UA in the CSF is determined by the serum UA concentration and the integrity of the BBB and is always approximately 10% of its peripheral concentration [195]

doi:10.1056/NEJMoa2410027 11

C.C: compound C, EX-4: exendin-4, IL-1: interleukin-1, IL-6: interleukin 6, TGF-: transforming growth factor-, TNF: tumor necrosis factor, TZP: tirzepatide