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Long-chain fatty acids cannot cross the inner mitochondrial membrane on their own and it is inside the mitochondrion that they are burned (-oxidation)
PQQ helps build the "power plants" (mitochondria), and glutathione protects those power plants from the "smoke" (oxidative stress) they produce
The peptide might look dissolved, but functionally, it could be useless
Therefore, semaglutide, tirzepatide, and retatrutide are expected to be safer and more effective treatments for MC4R-deficient obesity than setmelanotide
Oxidative Medicine and Cellular Longevity, 2020, 113
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