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Chem Rev 121:17461803

The standard NHS regimen for treating deficiency involves loading doses followed by maintenance therapy, with frequency determined by the underlying cause and severity of deficiency

These studies focus on molecular mechanisms and assay readouts, not therapeutic use

Common clinic signs include: Chronic or recurring vomiting Diarrhea (often with mucus or blood) Weight loss Lethargy Poor coat quality Decreased appetite These symptoms often appear gradually and may come and go, making them easy to overlook at first