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It comes in four dosage strengths: 3.75 mg phentermine / 23 mg topiramate (starting dose, taken for 14 days) 7.5 mg phentermine / 46 mg topiramate (recommended dose) 11.25 mg phentermine / 69 mg topiramate (titration dose) 15 mg phentermine / 92 mg topiramate (top dose) The dosing follows a gradual escalation

However, when these side effects appear relative to your schedule can be managed through dosing logistics

Importantly, these medications are not generally recommended in patients with severe gastrointestinal disease, including severe gastroparesis, which may be relevant when considering their use in individuals with Crohn's disease

Based on the current safety data, experts encourage people to think carefully about whether glutathione injections are worth the risk

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