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However, as the popularity of GLP-1 drugs has surged, so have reports of serious side effects, such as stomach paralysis, intestinal obstructions and vision loss

Protein is the most satiating macronutrient, ii keep you full and satisfied for longer in part because protein increases the release of GLP-1 as well as another satiety influencig hormone (PYY or peptide YY)

Full therapeutic effects for weight management should be evaluated after 12 weeks at a maintenance dose (typically 10-15 mg weekly), while glycemic response for diabetes is assessed after 3-6 months on a stable dose

These structures consist of repetitive nucleotide sequences that safeguard genetic information during cell division

Pregnancy and Breastfeeding Neither Semaglutide nor Tirzepatide is recommended for those who are currently pregnant, planning to become pregnant within the next six months, or breastfeeding , due to limited research on safety in these conditions

Executive Vice President & President, Lilly Cardiometabolic Health, Eli Lilly and Company Why this matters 1 Triple agonist = next-gen metabolic therapy Mimics GLP-1, GIP, and glucagon multi-pathway metabolic control 2 Diabetes + obesity convergence Simultaneous A1C + weight control = major unmet need solved 3 Competitive landscape shift Raises the bar vs GLP-1 mono & dual incretin therapies 4 No plateau signal is critical Suggests longer-term sustained efficacy Safety profile (expected class effects) Nausea, diarrhea, vomiting (dose-escalation phase) Discontinuation rates relatively low (25%) My takeaway 1 Metabolic disease treatment is entering multi-hormone era 2 Obesity + diabetes becoming one therapeutic category 3 Efficacy approaching bariatric-level outcomes 4 Sets new benchmark for Novo Nordisk and competitors Bottom line: Retatrutide isnt just competing Its redefining how we treat metabolic disease at the systems level #Diabetes #Obesity #GLP1 #Biotech #ClinicalTrials #Pharma #Innovation To view or add a comment, sign in 2,744 followers