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IGF-1 elevation is the primary mechanism through which full HGH increases the risk of insulin resistance, fluid retention, and certain growth-related effects at high doses

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Pancreatic cell dedifferentiation as a mechanism of diabetic cell failure

Clin Chem (2003) 49(6):94552.10.1373/49.6.945 25 TuckKLHayballPJStupansI

With vitamin C, your skin will gradually return to its baseline as existing brightening effects fade, but the protective benefits against sun damage provide lasting value