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They were initially defined as secretory GPX, but later studies have shown that both enzymes are localized to the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins (Figure 8)

2.5.2 The Keap1-NRF2 pathway mediates ferroptosis The NRF2 transcription factor stimulates the production of NADPH by blocking the expression of antioxidant genes and increasing the expression of enzymes in the pentose phosphate pathway, which decreases the sensitivity of cells to ferroptosis (85)

Rothan et al

Type 2 diabetes contributes to altered adaptive immune responses and vascular inflammation in patients with SARS-CoV-2 infection

10.1161/CIRCULATIONAHA.113.007124 Circulation

It catalyses the condensation of gamma-glutamylcysteine and glycine, to form glutathione