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Semaglutide, liraglutide, dulaglutide, and related agents improve glycemic control, promote weight loss, and may reduce cardiovascular risk in selected patients

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GLP-1RAs directly stimulate POMC/CART neurons and indirectly inhibit NPY and AgRP to increase measures of satiety and decrease hunger, resulting in reduced energy intake, thereby facilitating weight loss (Figure 6)

EBioMedicine 28 , 187193, (2018)