Lam B et al
An observational study of obese T2D patients with concurrent MASLD (metabolic dysfunction-associated steatotic liver disease) showed that 12 weeks of liraglutide significantly increased gut bacterial diversity and shifted the community toward a profile more like healthy individuals ( Bacteroidota and Proteobacteria (class Bacilli also increased), whereas an active comparator (metformin) enriched different taxa ( Fusobacteria and Actinobacteria ) and had a larger effect on network connectivity of the microbiota
May your drops stay potent, your hold times stay long, and your results stay consistent.
In addition, incretin enthusiasts had suffered a serious disappointment, when it was observed, at about the same time, that GIP although being potently insulinotropic in healthy individuals was ineffective in patients with type 2 diabetes ( not including secretin) also was a potent inhibitor of glucagon secretion ( Inspired by the similarity of GLP-1 with glucagon and oxyntomodulin, it was relevant to look at other glucagon-like gastro-intestinal actions of GLP-1, and via extensive human studies it was soon established that GLP-1 was a physiological and powerful inhibitor of gastrointestinal secretion (both gastric and pancreatic) and motility ( In spite of the disappointment with GIP in T2DM, it was time to see whether the new incretin would have any effects in T2DM patients
Nitrogen metabolism in the rumen
It includes multiple trials studying retatrutide in different patient populations and for different indications