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Our study showed that HepG2 cells, which primarily rely on extracellular cystine as a source of cysteine 20 , responded to cystine deprivation by reducing anabolic signaling including attenuation of mTORC1 pathway and activation of the ISR (Fig
Mihura, J
Gastrointestinal Issues Nausea Vomiting Constipation Abdominal discomfort Up to 50% of patients experience GI distress, especially at the start
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Bermea, K
Clinical trials indicate that the medication is safe for extended use, with most patients experiencing mild to moderate gastrointestinal side effects such as nausea, vomiting, diarrhea, or constipation
