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Efficacy, safety and cardiovascular outcomes of once-daily oral semaglutide: the PIONEER programme
During the early weeks, lower doses help reduce the likelihood of gastrointestinal side effects, such as nausea or constipation
Ideally incorporate rigorous baseline and follow-up assessments: DEXA, body composition, visceral fat, renal function, endocrine panels, inflammatory biomarkers (IL-6, TNF-, SASP markers if available)
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Nakanishi, N
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