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chloramphenicol), and concurrent iron or folic acid deficiency.[12][23] Therefore, these factors should be taken into consideration and regular monitoring should be performed in these conditions while treating vitamin B12 deficiency with cyanocobalamin

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However, owing to the lack of consideration for brain capillary binding or sequestration, the reliability of these results regarding brain uptake pharmacokinetics has been questioned [21] as well as whether results could be translated into humans