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These minor side effects include reduced appetite, nausea, vomiting, diarrhea, headaches, and dizziness

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration

4.2 CAPE Research has gone into the effects of loading CAPE into NPs to increase its bioavailability

Water can be contaminated by leaking or failing septic systems, runoff and flooding that carry waste into a well, cracks in the well casing, a damaged or loose well cap, and surface water seeping in around a poorly sealed wellhead

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