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[6] Research shows that these effects are dependent on PepT1, a peptide transporter that becomes upregulated in inflamed intestinal tissue
The IL-1 signaling pathway is implicated in acute doxorubicin-induced cardiotoxicity, with increased expression of IL-1, IL-1Ra, and IL-1RI correlating with cardiac damage [87]
However, no human studies have examined truly long-term use extending over years or decades
2009;38:396 Raffa M, Mechri A, Othman LB, Fendri C, Gaha L, Kerkeni A
trials in healthy adults are small and limited in scope
