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Semaglutide, the active ingredient in Ozempic and Wegovy, and tirzepatide, the active ingredient in Mounjaro and Zepbound, have shifted this paradigm

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This notion was confirmed using metabolic cages, revealing that GLP-1MK-801 counteracted the decrease in energy expenditure that is engaged by calorie-restricted mammals as an adaptive starvation response to protect the organism from an excessive loss of body weight and fat mass (Fig