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Drinking more fluids than is advised between hemodialysis sessions might result in life-threatening consequences including heart failure or fluid buildup in your lungs (pulmonary edema), as fluid is removed from your body during hemodialysis

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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

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