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This finding prompted the FDA to expand Wegovy's indication in March 2024 to include cardiovascular risk reduction

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In fact, a cortactin mutation interrupting the binding to the Arp2/3 complex has been demonstrated to reduce the number of internalized bacteria into endothelial cells (Slanina et al., 2012)

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These results may stem from CYP-mediated ASM interactions linked to metabolic pathways and oxidative stress implicating a unique feature based on ASM combination, not solely a disease pathogenesis per se