Metabolic secondary outcomes included HbA1c, blood pressure (systolic and diastolic), HR, total cholesterol, triglycerides, hsCRP, HbA1c in participants with pre-existing pre-diabetes and T2D, blood pressure in participants with pre-existing hypertension and changes in T2D, and hypertension medication used in participants with T2D and hypertension, respectively
Results were confirmed in analyses pooling data with an additional internal replication sample from the same subjects measured at 6-year follow-up (totaling 4141 observations)
GLP-1 medications Glucagon-like peptide-1 (GLP-1) agonists are a class of medications that work by reducing appetite and slowing digestion, which helps you feel fuller for longer
Unlike semaglutide, orlistats effects are tied directly to fat intake
Though why we are driven to over consume in response to normal activity is unclear
Since edibles rely on digestion before effects are felt, delayed gastric emptying from GLP-1 medications may make the timing of edibles feel less predictable